David J Craik Selected Research

Cyclotides

1/2024	Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide.
1/2023	Plant-based production of an orally active cyclotide for the treatment of multiple sclerosis.
1/2022	Protocols for measuring the stability and cytotoxicity of cyclotides.
11/2021	Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides.
1/2020	Exploring the Sequence Diversity of Cyclotides from Vietnamese Viola Species.
1/2016	Using the MCoTI-II Cyclotide Scaffold To Design a Stable Cyclic Peptide Antagonist of SET, a Protein Overexpressed in Human Cancer.
11/2015	Lysine-rich Cyclotides: A New Subclass of Circular Knotted Proteins from Violaceae.
1/2015	Effects of cyclotides against cutaneous infections caused by Staphylococcus aureus.
9/2014	Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting.
11/2012	Design, synthesis, structural and functional characterization of novel melanocortin agonists based on the cyclotide kalata B1.

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David J Craik Research Topics

Disease

48	Neoplasms (Cancer) 01/2024 - 08/2009
26	Pain (Aches) 12/2023 - 06/2004
14	Neuralgia (Stump Neuralgia) 01/2022 - 08/2006
8	Infections 11/2023 - 03/2011
7	Chronic Pain 01/2023 - 04/2016
5	Bacterial Infections (Bacterial Infection) 11/2023 - 10/2010
4	Multiple Sclerosis 01/2023 - 01/2014
4	Melanoma (Melanoma, Malignant) 12/2020 - 01/2017
3	Obesity 10/2023 - 07/2008
3	Malaria 01/2023 - 01/2018
3	Hemorrhage 12/2022 - 08/2016
3	Thrombosis (Thrombus) 12/2022 - 08/2016
3	Prostatic Neoplasms (Prostate Cancer) 10/2022 - 12/2018
3	Hypercholesterolemia 11/2021 - 01/2021
3	Cardiovascular Diseases (Cardiovascular Disease) 08/2021 - 01/2020
3	Visceral Pain 01/2021 - 01/2018
3	Leukemia 12/2020 - 01/2017
3	Breast Neoplasms (Breast Cancer) 10/2019 - 01/2007
3	Inflammation (Inflammations) 08/2019 - 03/2008
3	Schizophrenia (Dementia Praecox) 12/2017 - 02/2012
3	Parkinson Disease (Parkinson's Disease) 01/2013 - 04/2010
2	Mycoses (Diseases, Fungus) 11/2023 - 12/2019
2	Abdominal Pain (Pain, Abdominal) 01/2021 - 01/2018
2	Type 2 Diabetes Mellitus (MODY) 01/2016 - 10/2015
2	Tobacco Use Disorder (Nicotine Dependence) 01/2013 - 04/2010
1	Onychomycosis (Tinea Unguium) 11/2023
1	Intractable Pain 02/2023
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2023
1	Carcinogenesis 10/2022
1	Pathologic Processes 10/2022
1	Amyloid Plaque 10/2022
1	Cancer Pain 01/2022
1	Communicable Diseases (Infectious Diseases) 01/2022

Drug/Important Bio-Agent (IBA)

47	Peptides (Polypeptides)IBA 11/2023 - 01/2005
20	Conotoxins (Conotoxin)IBA 01/2023 - 06/2004
17	CyclotidesIBA 01/2024 - 01/2007
12	Analgesics (Analgesic Drugs)IBA 01/2023 - 03/2008
11	Proteins (Proteins, Gene)FDA Link 01/2024 - 12/2002
11	DisulfidesIBA 01/2023 - 01/2005
11	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2022 - 03/2008
9	Cyclic PeptidesIBA 01/2024 - 01/2014
5	DefensinsIBA 11/2023 - 09/2007
5	gomesinIBA 03/2023 - 03/2013
5	Anti-Bacterial Agents (Antibiotics)IBA 01/2023 - 10/2013
5	Antimicrobial PeptidesIBA 01/2023 - 01/2017
5	VenomsIBA 11/2020 - 10/2008
5	Voltage-Gated Sodium ChannelsIBA 01/2020 - 05/2016
5	LipidsIBA 08/2019 - 07/2008
5	ChlorotoxinIBA 09/2017 - 02/2011
4	ziconotide (Prialt)FDA Link 02/2023 - 06/2012
4	Peptide Hydrolases (Proteases)FDA Link 01/2019 - 12/2009
4	Serine Proteases (Serine Protease)IBA 12/2018 - 06/2011
4	trypsin inhibitor MCoTI-IIIBA 10/2016 - 01/2007
3	Cell-Penetrating PeptidesIBA 01/2024 - 01/2021
3	Antimalarials (Antimalarial Agents)IBA 01/2023 - 01/2013
3	EnzymesIBA 01/2020 - 01/2008
3	Anti-Infective Agents (Microbicides)IBA 12/2019 - 01/2010
3	Ion Channels (Ion Channel)IBA 01/2018 - 01/2015
3	kalata B1IBA 09/2014 - 01/2007
2	LigandsIBA 10/2023 - 11/2021
2	Factor XIIa (Coagulation Factor XIIa)IBA 12/2022 - 08/2016
2	Lactate Dehydrogenase 5IBA 11/2022 - 01/2021
2	SodiumIBA 01/2022 - 07/2015
2	Tachypleus tridentatus tachyplesin peptideIBA 12/2021 - 08/2019
2	CalciumIBA 08/2021 - 07/2015
2	Proprotein Convertase 9IBA 01/2021 - 01/2021
2	Antimicrobial Cationic PeptidesIBA 01/2021 - 10/2010
2	cycloviolacin O2IBA 01/2020 - 09/2014
2	Spider Venoms (Venom, Spider)IBA 01/2019 - 12/2016
2	Sodium Channels (Sodium Channel)IBA 01/2019 - 06/2004
2	Kallikreins (Kallikrein)IBA 12/2018 - 07/2015
2	Lipid Bilayers (Lipid Bilayer)IBA 05/2017 - 09/2014
2	Cisplatin (Platino)FDA LinkGeneric 01/2017 - 09/2014
2	Hormones (Hormone)IBA 10/2016 - 03/2015
2	Angiogenesis InhibitorsIBA 10/2016 - 01/2010
2	EpitopesIBA 01/2016 - 09/2014
2	Phospholipids (Phosphatides)FDA LinkGeneric 08/2015 - 09/2014
2	phosphatidylethanolamineIBA 08/2015 - 09/2014
2	bcr-abl Fusion ProteinsIBA 08/2015 - 01/2013
2	Chymotrypsin FDA Link 07/2015 - 01/2008
2	TrypsinIBA 07/2015 - 01/2008
2	kalata B2IBA 01/2015 - 09/2014
2	Nicotine FDA Link 12/2013 - 02/2012
2	matriptaseIBA 05/2013 - 06/2011
2	Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA 11/2006 - 01/2005
1	mastoparanIBA 11/2023
1	Formaldehyde (Formol)FDA Link 01/2023
1	Immunoconjugates (Immunoconjugate)IBA 01/2023
1	Morphine (MS Contin)FDA LinkGeneric 01/2023
1	Biomarkers (Surrogate Marker)IBA 10/2022
1	RNA (Ribonucleic Acid)IBA 10/2022
1	MicropeptidesIBA 10/2022
1	Prealbumin (Transthyretin)IBA 10/2022
1	peptide AIBA 10/2022
1	Antineoplastic Agents (Antineoplastics)IBA 01/2022
1	Conus generalis alpha-conotoxinIBA 01/2022
1	ThioninsIBA 01/2022
1	NeurotoxinsIBA 01/2022

Therapy/Procedure

17	Therapeutics 12/2023 - 02/2011
3	Analgesia 11/2020 - 03/2008